Insecticidal agent 33
Insecticidal agent 33 is an AChE inhibitor with nematicidal activity. Insecticidal agent 33 impairs locomotor activity of Caenorhabditis elegans, and induces oxidative damage in Caenorhabditis elegans, including elevated reactive oxygen species (ROS) levels, lipofuscin accumulation, lipid deposition, and disrupted cellular homeostasis. Insecticidal agent 33 can be used for the research of plant-parasitic nematode infection.
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- 화학식: C21H15N3O3S
- 분자량:389.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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AChE |
Insecticidal agent 33 (compound A18) (48 h) potently kills Caenorhabditis elegans with an LC50 of 4.19 mg/L, achieving 100% nematicidal activity[1].
Insecticidal agent 33 (48 h) exhibits 65.5% nematicidal activity against Bursaphelenchus xylophilus[1].
Insecticidal agent 33 (48 h) kills Meloidogyne incognita with an LC50 of 21.15 mg/L, achieving 79.6% nematicidal activity that is comparable to positive control Tioxazafen (HY-136240)[1].
Insecticidal agent 33 (50 mg/L) potently inhibits acetylcholinesterase activity in Caenorhabditis elegans[1].
Insecticidal agent 33 binds to the active pocket of acetylcholinesterase via hydrogen bonds with residues Phe-288, Arg-289, and Ser-286, supporting its potent inhibitory activity against the enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C. elegans[1]
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Dosage:5; 10; 12.5; 20; 25; 30; 40; 50; 100 mg/L
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Administration:single treatment
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Result:Dose-dependently impaired locomotor activity of C. elegans.
Induced oxidative damage.
Elevated reactive oxygen species (ROS) levels, lipofuscin accumulation, lipid deposition, and disrupted cellular homeostasis.
Chemical Information
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분자량 389.43
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화학식 C21H15N3O3S
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SMILES
COC1=CC=C2C(N=C(CO2)C3=CC=C(C=C3)C4=NOC(C5=CC=CS5)=N4)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Insecticidal agent 33 Related Classifications
HY-183949 Related Classifications
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- Insecticidal agent 33
- Insecticidal agent33
- Insecticidal agent-33
- Insecticide
- Cholinesterase (ChE)
- Reactive Oxygen Species (ROS)
- oxidative damage
- Meloidogyne incognita
- Bursaphelenchus xylophilus
- oxidative stress
- plant-parasitic nematode infection
- reactive oxygen species
- acetylcholinesterase
- tomato seedlings
- Caenorhabditis elegans
- lipofuscin
- Inhibitor
- inhibitor
- inhibit