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United States

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Cat. No.: HY-124374

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J-104123

J-104123 is an inhibitor of squalene synthase with monocarboxylic acid structure. J-104123 can lower serum cholesterol level in dog models.

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CAS No.: 162037-54-9
화학식: C₂₈H₂₉Cl₂NO₃
분자량:498.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

J-104123 Chemical Structure

CAS No.: 162037-54-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

J-104123 is an inhibitor of squalene synthase with monocarboxylic acid structure. J-104123 can lower serum cholesterol level in dog models^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	2.5 nM Compound: J-104123	Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cells	10.1016/0960-894X(96)00033-9

Chemical Information

CAS No. 162037-54-9
분자량 498.44
화학식 C₂₈H₂₉Cl₂NO₃
SMILES

O=C(C[C@@H](CC(N[C@@H](C)[C@H](/C=C/C1=CC=C2C=CC=CC2=C1)CC3=CC=C(C(Cl)=C3)Cl)=O)C)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yoshikazu Iwasawa, et al (1996). J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs. Bioorganic & Medicinal Chemistry Letters 6(4) 463-466.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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