JTK-109
Based on 1 Customer Validation
JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC50 value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) .
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.68%
- CAS No.: 480462-62-2
- 화학식: C37H33ClFN3O4
- 분자량:638.13
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 0.017μM (NS5B)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-5-2 | CC50 |
>20 μM
Compound: 1
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Cytotoxicity against Huh-5-2 cells
Cytotoxicity against Huh-5-2 cells
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[PMID: 17383878] |
| Huh-5-2 | CC50 |
25 μM
Compound: 10n
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Viability of Huh5-2 cells by MTT assay
Viability of Huh5-2 cells by MTT assay
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[PMID: 16854079] |
| Huh-5-2 | EC50 |
0.32 μM
Compound: 1
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Antiviral activity against HCV in Huh-5-2 cells by replicon assay
Antiviral activity against HCV in Huh-5-2 cells by replicon assay
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[PMID: 17383878] |
| Huh-5-2 | EC50 |
0.32 μM
Compound: 10n
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Inhibition of HCV subgenomic RNA replication in Huh5-2 cells after 48 hrs by replicon assay
Inhibition of HCV subgenomic RNA replication in Huh5-2 cells after 48 hrs by replicon assay
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[PMID: 16854079] |
Chemical Information
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CAS No. 480462-62-2
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Appearance Solid
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분자량 638.13
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화학식 C37H33ClFN3O4
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Color White to off-white
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SMILES
O=C(C1=CC=C2C(N=C(C3=CC=C(OCC4=CC(N5C(CCC5)=O)=CC=C4C6=CC=C(Cl)C=C6)C=C3F)N2C7CCCCC7)=C1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Hirashima S, et al. Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3181-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JTK-109 Related Classifications
HY-19643 Related Classifications
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