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Cat. No.: HY-P11621

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JWP24

JWP24 is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC₅₀ of 200 nM against human MAGE-A4. JWP24 binds to intracellular targets while retaining binding activity, disrupts the interaction between MAGE-A4 and RAD18, and does not induce cytotoxicity at effective concentrations. JWP24 is applicable for cancer-related research.

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화학식: C₆₈H₈₉FN₁₂O₁₂S₂
분자량:1349.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

JWP24 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

RAD18

In Vitro

JWP24 (0.005-80 μM; 1.5 h) potently disrupts the interaction between MAGE-A4 and RAD18 in HEK293 cells, with an IC₅₀ of 0.5 μM, and exhibits no cytotoxicity at effective concentrations^[1].
JWP24 (10 μM; 2 h) inhibits the interaction between MAGE-A4 and RAD18 in H1299 cell lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

H1299 cells (transiently transfected with plasmids expressing Myc-RAD18 and HA-MAGE-A4)
Concentration:

10 μM
Incubation Time:

2 h
Result:

Bound to the conserved MHD of MAGE-A4 and effectively inhibit the MAGE-A4/RAD18 interaction.

Chemical Information

분자량 1349.64
화학식 C₆₈H₈₉FN₁₂O₁₂S₂
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lim J, et al. Development of Next Generation Cell-Permeable Peptide Inhibitors for the Oncological Target MAGE-A4. J Med Chem. 2025;68(18):19377-19395. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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