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Cat. No.: HY-182411

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KRAS-IN-56

KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC₅₀ of 33 μM. KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1. KRAS-IN-56 induces a decrease in p-ERK levels. KRAS-IN-56 can be used in research related to lung cancer.

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CAS No.: 2375482-34-9
화학식: C₁₉H₁₉N₃O₂
분자량:321.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-56 Chemical Structure

CAS No.: 2375482-34-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
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Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

K-RAS

33 μM (EC₅₀)

All Ras Isoforms :

In Vitro

KRAS-IN-56 binds to the purified GCP-KRAS^G12D protein, with a measured K_d value of 20 μM via ITC^[1].
KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1 in a biochemical assay, with an EC₅₀ of 33 μM^[1].
KRAS-IN-56 (10^-8-10^-4 M; 2 h) induces a dose-dependent decrease in pERK levels in NCI-H358 KRAS^G12C mutant lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2375482-34-9
분자량 321.37
화학식 C₁₉H₁₉N₃O₂
SMILES

CN(C)CC1=C([C@@H]2C3=CC(O)=CC=C3C(N2)=O)C4=CC=CC=C4N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019;116(32):15823-15829. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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- In Vitro
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KRAS-IN-56

All Ras Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KRAS-IN-56 Related Classifications

HY-182411 Related Classifications