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Cat. No.: HY-117952

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L 743310

L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis.

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CAS No.: 187724-86-3
화학식: C₃₀H₃₃BrF₆N₄O₂
분자량:675.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

L 743310 Chemical Structure

CAS No.: 187724-86-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

hNK1 receptor^[1]

All Neurokinin Receptor Isoforms :

Chemical Information

CAS No. 187724-86-3
분자량 675.50
화학식 C₃₀H₃₃BrF₆N₄O₂
SMILES

C[N+]1(CC2)CCC2(NC(NC(CC3=CNC4=C3C=CC=C4)C(CCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)=O)CC1.[Br-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tachykinin NK1 Receptor Antagonists Act Centrally to Inhibit Ernesis Induced by the Chemotherapeutic Agent Cisplatin in Ferrets

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
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L 743310

All Neurokinin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

L 743310 Related Classifications

HY-117952 Related Classifications