country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-161417

Copy Link Print Information

LIMK-IN-2

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2747216-27-7
화학식: C₂₈H₂₇N₅O₂
분자량:465.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LIMK-IN-2 Chemical Structure

CAS No.: 2747216-27-7

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity^[1].

All LIM Kinase (LIMK) Isoforms :

LIMK1
LIMK2

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	EC₅₀	>25 μM Compound: 52	Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis	[PMID: 38669909]
HeLa	EC₅₀	26 μM Compound: 52	Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay	[PMID: 38669909]
KHOS/NP	IC₅₀	6.2 μM Compound: 52	Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38669909]
U2OS	IC₅₀	9.5 μM Compound: 52	Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay	[PMID: 38669909]

Chemical Information

CAS No. 2747216-27-7
분자량 465.55
화학식 C₂₈H₂₇N₅O₂
SMILES

COC1=CC=CC(C2=CC(NC(N3CCC(C4=C5C(NC=C5C6CC6)=NC=N4)=CC3)=O)=CC=C2)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Champiré A, et al. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. Eur J Med Chem. Published online April 9, 2024. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

LIMK-IN-2

All LIM Kinase (LIMK) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LIMK-IN-2 Related Classifications

HY-161417 Related Classifications