MM0299
Based on 1 Customer Validation
MM0299 is a selective lanosterol synthase (LSS) inhibitor with an IC50 value of 2.22 μM. MM0299 depletes intracellular cholesterol and acts as a growth inhibitor for glioma stem-like cells. MM0299 exhibits anti-glioblastoma activity. MM0299 is applicable to research related to glioblastoma.
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- Purity: 98.51%
- CAS No.: 474255-10-2
- 화학식: C26H23NO5
- 분자량:429.46
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
MM0299 (96 h) potently inhibits the proliferation of glioma stem-like cells from Mut6 mice, with an IC50 value of 0.0182 μM[1].
MM0299 (0.1 μM) inhibits lanosterol synthase activity in glioma stem-like cells from Mut6 mice, leading to a dose-dependent decrease in intermediates of the canonical cholesterol pathway (lanosterol IC50 = 0.0455 μM)[1].
MM0299 alters gene expression, upregulating LXR target genes and downregulating SREBP target genes, which reflects the activation of the cholesterol efflux pathway and the inhibition of the cholesterol biosynthesis pathway in glioma stem-like cells from Mut6 mice[1].
MM0299 (120 h) inhibits the proliferation of UTSW63 and UTSW71 human glioma stem-like cells, with IC50 values of 0.0222 μM and 0.0212 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mut6 mouse glioma stem-like cells
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Concentration:/
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Incubation Time:96 h
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Result:Reduced the viability of Mut6 cells in a dose-dependent manner, with an IC50 of 0.0182 μM.
Chemical Information
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CAS No. 474255-10-2
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Appearance Solid
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분자량 429.46
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화학식 C26H23NO5
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Color Light yellow to brown
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SMILES
O=C(N1C(C=C2)=CC=C2OCC(C(C=C3)=CC=C3OC)=O)C4C(C1=O)[C@@H]5[C@@H]6C(C6)[C@H]4C=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (291.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3285 mL | 11.6425 mL | 23.2851 mL | 58.2126 mL |
| 5 mM | 0.4657 mL | 2.3285 mL | 4.6570 mL | 11.6425 mL | |
| 10 mM | 0.2329 mL | 1.1643 mL | 2.3285 mL | 5.8213 mL | |
| 15 mM | 0.1552 mL | 0.7762 mL | 1.5523 mL | 3.8808 mL | |
| 20 mM | 0.1164 mL | 0.5821 mL | 1.1643 mL | 2.9106 mL | |
| 25 mM | 0.0931 mL | 0.4657 mL | 0.9314 mL | 2.3285 mL | |
| 30 mM | 0.0776 mL | 0.3881 mL | 0.7762 mL | 1.9404 mL | |
| 40 mM | 0.0582 mL | 0.2911 mL | 0.5821 mL | 1.4553 mL | |
| 50 mM | 0.0466 mL | 0.2329 mL | 0.4657 mL | 1.1643 mL | |
| 60 mM | 0.0388 mL | 0.1940 mL | 0.3881 mL | 0.9702 mL | |
| 80 mM | 0.0291 mL | 0.1455 mL | 0.2911 mL | 0.7277 mL | |
| 100 mM | 0.0233 mL | 0.1164 mL | 0.2329 mL | 0.5821 mL |
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