MMV675968
MMV675968 is an inhibitor of Acinetobacter baumannii dihydrofolate reductase (AbDHFR) with an IC50 of 8.5 nM, and it exhibits selectivity against human DHFR. MMV675968 inhibits dihydrofolate reductase in Cryptosporidium, Plasmodium, and Escherichia coli, disrupting the thymidylate cycle and folate biosynthesis pathway. MMV675968 inhibits the growth of multiple A. baumannii strains, including clinical isolates and environmental isolates. MMV675968 is applicable to research related to A. baumannii infections.
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- CAS No.: 159308-73-3
- 화학식: C17H18ClN5O2
- 분자량:359.81
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
25 μM
Compound: 48; MMV675968
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
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[PMID: 30647879] |
In Vitro
MMV675968 selectively inhibits A. baumannii DHFR but not human DHFR, with an IC50 of 8.5 nM against A. baumannii DHFR and an IC50 of 492.4 nM against human DHFR[1].
MMV675968 (0.6-10 μM; 18 h) inhibits the growth of Acinetobacter baumannii (A. baumannii) strains Mahidol, Naval-81, H72721 and 3-137, with IC50 values of 0.6-2.7 μM, IC90 values of 0.7-3.9 μM, and MIC values of 1.6-10 μM[1].
MMV675968 (10 μM; 18 h) inhibits the growth of E. coli PA414 surrogate cells expressing A. baumannii DHFR, but exerts no such effect on these cells expressing human DHFR[1].
MMV675968 (10 μM; 90 min) inhibits endogenous DHFR activity in Acinetobacter baumannii strains Mahidol, Naval-81, H72721, and 3-137[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 159308-73-3
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분자량 359.81
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화학식 C17H18ClN5O2
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SMILES
ClC1=C2C(N)=NC(N)=NC2=CC=C1CNC3=CC(OC)=CC=C3OC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMV675968 Related Classifications
HY-182684 Related Classifications
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