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Cat. No.: HY-182062

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NAMPT activator-9

NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC₅₀ of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD⁺ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy.

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CAS No.: 931366-46-0
화학식: C₁₇H₁₅N₅O
분자량:305.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NAMPT activator-9 Chemical Structure

CAS No.: 931366-46-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

NAMPT activator-9 (60 min) is a potent allosteric activator of hNAMPT, with an EC₅₀ of 3.366 μM^[1].
NAMPT activator-9 (0.741-20 μM; 24 h) significantly increases the intracellular NAD⁺ level and NAD⁺/NADH ratio in fully differentiated C2C12 myotubes; after treatment with 2.222 μM for 24 h, the NAD⁺ level increases by approximately 2-fold^[1].
NAMPT activator-9 (2.222-20 μM; 24 h) protects fully differentiated C2C12 myotubes against Dexamethasone (HY-14648)-induced atrophy by reducing the expression of atrophy markers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Fully differentiated C2C12 myotubes
Concentration:

0.247-4860 μM
Incubation Time:

24 h
Result:

Showed no obvious toxicity in C2C12 myotubes up to 180 μM, with an IC₅₀ value of 1.98 mM.

Western Blot Analysis^[1]

Cell Line:

Fully differentiated C2C12 myotubes (dexamethasone-induced atrophy model)
Concentration:

2.222-20 μM (co-incubated with 10 μM dexamethasone)
Incubation Time:

24 h
Result:

Nearly completely abolished Dexamethasone-induced upregulation of Atrogin-1 and MuRF1 expression.
Reversed dexamethasone-induced reduction of MyHC expression, with significant recovery at all tested concentrations.

Chemical Information

CAS No. 931366-46-0
분자량 305.33
화학식 C₁₇H₁₅N₅O
SMILES

O=C(N1CC2=C(C=CC=C2)CC1)C3=CC=C(C4=NNN=N4)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li L, et al. Computer assisted discovery of novel nicotinamide phosphoribosyltransferase agonists to combat muscle atrophy. Bioorg Chem. 2026;168:109296. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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