NK3201
NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein.
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- CAS No.: 204460-24-2
- 화학식: C31H29N5O6
- 분자량:567.59
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 204460-24-2
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분자량 567.59
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화학식 C31H29N5O6
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SMILES
O=C(NC(CC1=CC=CC=C1)C(C(CCCOC2=NC=CC=C2)=O)=O)CN(C(C3=CC=CC=C3)=NC=C4NC=O)C4=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Sakaguchi M, et al. A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters. Eur J Pharmacol. 2004 Jun 16;493(1-3):173-6. [Content Brief]
[2]. Takai S, et al. Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein. Life Sci. 2001 Aug 31;69(15):1725-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NK3201 Related Classifications
HY-12514 Related Classifications
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