NU-7107
NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 >10 μM. NU-7107 is applicable for cancer research.
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- CAS No.: 503465-21-2
- 화학식: C18H19N3O2
- 분자량:309.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
3.25 μM
Compound: 94
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Inhibition of DNA dependent protein kinase isolated from HeLa cells
Inhibition of DNA dependent protein kinase isolated from HeLa cells
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[PMID: 15658870] |
In Vitro
Parmacokinetics
| Species | Dose | Route | Cmax | Tmax | T1/2 | Vd |
|---|---|---|---|---|---|---|
| Mice[1] | 20 mg/kg | i.p. | 10390 nM | 0.25 h | 0.79 h | 0.12 L |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female)[1]
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Dosage:20 mg/kg
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Administration:i.p.; single dose
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Result:Reached a maximum plasma concentration (Cmax) of 10390 nmol/L.
Reached time to maximum concentration (Tmax) of 0.25 h.
Achieved area under the concentration vs time curve (AUC last) of 12165 nmol·h/L.
Had a terminal half-life (t1/2) of 0.79 h.
Had plasma clearance (CI obs.) of 0.11 L/h.
Had volume of distribution (Vd) of 0.12 L.
Remained detectable in plasma 6 hours post-administration.
Exhibited plasma clearance four-fold slower than that of NU7026.
Chemical Information
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CAS No. 503465-21-2
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분자량 309.37
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화학식 C18H19N3O2
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SMILES
O=C1N2C(C=3C(C=C2)=CC=CC3)=NC(=C1)N4C[C@H](C)O[C@H](C)C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NU-7107 Related Classifications
HY-122176 Related Classifications
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