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Cat. No.: HY-W714300

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Nuarimol

Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury.

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CAS No.: 63284-71-9
화학식: C₁₇H₁₂ClFN₂O
분자량:314.74

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nuarimol Chemical Structure

CAS No.: 63284-71-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

Nuarimol (31.5-125 mg/kg; p.o.; once daily; for 1-5 consecutive days) induces dose-dependent, reversible hepatic effects in male Wistar rats, including increased p-nitroanisole O-demethylase activity, transient hepatocellular proliferation, and reversible hepatomegaly. Histological changes indicate that this is a regenerative response rather than a direct mitogenic response^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pzh:WIS (male, 200-210 g, acclimatized for 14 days under controlled environmental conditions)^[1]
Dosage:

31.5 mg/kg; 62.5 mg/kg; 125 mg/kg
Administration:

p.o.; once daily; 1, 3, or 5 consecutive days
Result:

Did not change liver weight.
Significantly increased p-nitroanisole O-demethylase activity.
Significantly increased the number of mitotic figures.
Observed cytoplasmic vacuolization (likely fatty changes) and focal hepatocyte destruction (suggesting piecemeal necrosis).

Chemical Information

CAS No. 63284-71-9
분자량 314.74
화학식 C₁₇H₁₂ClFN₂O
SMILES

FC1=CC=C(C=C1)C(O)(C=2C=NC=NC2)C=3C=CC=CC3Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kostka G, et al. Early hepatic changes induced by nuarimol in rats. J Appl Toxicol. 1994;14(5):337-342. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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