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Cat. No.: HY-108975

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OK-1035

OK-1035 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ of 100 μM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 98293-88-0
화학식: C₁₂H₉N₅O
분자량:239.23

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

OK-1035 Chemical Structure

CAS No.: 98293-88-0

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

OK-1035 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ of 100 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	100 μM Compound: 3 (OK-1035)	Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract	[PMID: 11597411]

In Vitro

OK-1035 (100 μM) is devoid of inhibitory activity against PI 3-kinase and ATM at a concentration of 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 98293-88-0
분자량 239.23
화학식 C₁₂H₉N₅O
SMILES

N#CC1=CC(C2=CC=NC=C2)=C(NC1=O)/C=N/N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Stockley M, et al. Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035). Bioorg Med Chem Lett. 2001;11(21):2837-2841. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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