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Cat. No.: HY-D3208

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oLOX

oLOX is a fluorescent activity reporter. oLOX can be activated by lysyl oxidase family (LOXF) enzymes, which in turn releases a luciferin fluorescent product that reports LOXF enzyme activity. After oLOX is activated in in vitro fibrotic lung tissues, the fluorescence intensity increases, enabling real-time detection of fibrotic activity. oLOX can be used in studies related to pulmonary fibrosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2241794-11-4
화학식: C₂₆H₂₆N₂O₅
분자량:446.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

oLOX Chemical Structure

CAS No.: 2241794-11-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

oLOX (10 μM; 2 h) exhibits up to a 300% increase in fluorescence in aged human lung tissue homogenate, with significant signal amplification detected after 30 min and signal plateauing between 50 min and 2 h^[1].
oLOX (200 μM) generates a significant increase in fluorescent signal in fibrotic regions of ventilating ex vivo asinine lung detectable via FCFM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2241794-11-4
분자량 446.50
화학식 C₂₆H₂₆N₂O₅
SMILES

NCCCOC1=CC2=C(C3(C4=C(O2)C=C(C=C4)OCCCN)OC(C5=C3C=CC=C5)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Aslam T, et al. Optical molecular imaging of lysyl oxidase activity - detection of active fibrogenesis in human lung tissue. Chem Sci. 2015;6(8):4946-4953. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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