OMTX005
Based on 1 Customer Validation
OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.44%
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Species Reactivity
Human
In Vitro
OMTX005 specifically binds to FAP-expressing HT1080-FAP cells and primary CAF07 cells, with EC50 values of 76 pM and 130 nM, respectively[1].
OMTX005 (5 days) does not reduce the viability of HT1080-WT, HT1080-FAP or primary CAF07 cells[1].
OMTX005 (400 nmol/L; 0-48 h) does not induce caspase 3/7 activity in HT1080-WT, HT1080-FAP or primary CAF07 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT1080-WT, HT1080-FAP, primary CAF07 cells
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Concentration:up to 400 nmol/L
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Incubation Time:5 days
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Result:Did not exhibit cytotoxic activity in any of the cell lines tested.
Gene ID
Accession
Target
FAP
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human FAP Protein, Fc Tag, active dimer can bind OMTX005. The EC50 for this effect is 39.8 ng/mL.
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[OMTX005]
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Synonyms
OMTX705 antibody
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OMTX005 Related Classifications
HY-P991995 Related Classifications
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