PD-134672
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
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- CAS No.: 135704-06-2
- 화학식: C33H52N6O7S2
- 분자량:708.93
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보관:
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Biological Activity
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Biological Activity
Chemical Information
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CAS No. 135704-06-2
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분자량 708.93
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화학식 C33H52N6O7S2
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SMILES
O=S(N[C@H](C(N[C@H](C(N[C@@]([C@@H](O)[C@@H](O)CC(C)C)([H])CC1CCCCC1)=O)CC2=CSC(N)=N2)=O)CC3=CC=CC=C3)(N4CCOCC4)=O
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Synonyms
CI-992
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-134672 Related Classifications
HY-19145 Related Classifications
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