IL-16
Interleukin-16 (IL-16) is a pro-inflammatory cytokine originally identified as lymphocyte chemoattractant factor (LCF). Unlike classical four-helix-bundle interleukins, IL-16 is synthesized as a large 631-amino-acid precursor (pro-IL-16) that is cleaved by caspase-3 to release the bioactive C-terminal fragment. IL-16 signals through CD4, and to a lesser extent CD9 and topical integrins, inducing chemotaxis of CD4+ T cells, monocytes, eosinophils and dendritic cells via a PI3K and STAT6-dependent mechanism, and upregulating IL-2Rα expression on T cells. It is abundantly produced by CD8+ T cells, eosinophils, mast cells and epithelial cells at sites of allergic inflammation and asthma. IL-16 also suppresses HIV replication by competing for CD4 and interfering with viral entry, and elevated levels are found in multiple sclerosis, sarcoidosis and certain lymphomas.
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IL-16 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
