IL-18BP
Interleukin-18 binding protein (IL-18BP) is a secreted, soluble regulator that constitutes the principal natural brake on IL-18 activity. It is not a truncated receptor but a distinct protein belonging to the immunoglobulin superfamily, constitutively present in human plasma at high concentrations and further induced by IFN-γ during inflammation. IL-18BP binds mature IL-18 with picomolar affinity, one order of magnitude higher than the affinity of IL-18 for its signaling receptor IL-18Rα, thereby neutralizing IL-18 and preventing IL-18Rβ recruitment and downstream MyD88-NF-κB activation. Through this mechanism, IL-18BP limits excessive IFN-γ production and protects against macrophage activation syndrome, inflammatory bowel disease, psoriasis and sepsis-associated immunopathology. Pseudomonas aeruginosa produces a viral IL-18BP homolog (PA2774) that disables this defense, and recombinant IL-18BP (tadekinig alfa) has been evaluated in clinical trials for autoinflammatory diseases.
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IL-18BP Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
