PIM3
Of the three PIM kinases, PIM3 is the one most tightly linked to epithelial stress responses; it is rapidly induced by stress stimuli and is highly expressed in kidney, brain and adrenal cortex. PIM3 is markedly upregulated in hepatocellular, pancreatic and colorectal carcinomas, where it phosphorylates BAD, MNK1 and translational regulators to suppress apoptosis and sustain growth. The three PIM paralogs share overlapping substrates and are constitutively active, yet PIM3 knockout mice display a distinct phenotype with reduced adipose tissue mass and lower circulating leptin, implicating it in lipid metabolism alongside its proliferative roles.
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PIM3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
