Pyronin B
Based on 1 Customer Validation
Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor.
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- CAS No.: 2150-48-3
- 화학식: C21H27ClN2O
- 분자량:358.90
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보관:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
2 μM
Compound: 2
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by flow cytometry
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by flow cytometry
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[PMID: 35647549] |
Pyronin B (0-15 μM) inhibits channel activity of approximately 60% of small hydrophobic (SH) proteins at a concentration of 10 μM, and the Kd value of 6.8 μM[1].
Pyronin B (0-0.25 μM) affects RSV replication in Vero cells in a dose-dependent manner, and its TCID50 (50% tissue culture infection dose) = 0 at the concentration of 0.25 μM[1].
Pyronin B (10 μM) can react with bromate in an oxidation reaction and the reaction rate increases dramatically with the addition of trace amounts of Ti (IV) with the characteristic absorption spectra of 555 nm[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2150-48-3
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Appearance Solid
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분자량 358.90
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화학식 C21H27ClN2O
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Color Brown to black
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SMILES
CCN(C1=CC2=[O+]C3=C(C=CC(N(CC)CC)=C3)C=C2C=C1)CC.[Cl-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : 20.83 mg/mL (58.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7863 mL | 13.9315 mL | 27.8629 mL | 69.6573 mL |
| 5 mM | 0.5573 mL | 2.7863 mL | 5.5726 mL | 13.9315 mL | |
| 10 mM | 0.2786 mL | 1.3931 mL | 2.7863 mL | 6.9657 mL | |
| 15 mM | 0.1858 mL | 0.9288 mL | 1.8575 mL | 4.6438 mL | |
| 20 mM | 0.1393 mL | 0.6966 mL | 1.3931 mL | 3.4829 mL | |
| 25 mM | 0.1115 mL | 0.5573 mL | 1.1145 mL | 2.7863 mL | |
| 30 mM | 0.0929 mL | 0.4644 mL | 0.9288 mL | 2.3219 mL | |
| 40 mM | 0.0697 mL | 0.3483 mL | 0.6966 mL | 1.7414 mL | |
| 50 mM | 0.0557 mL | 0.2786 mL | 0.5573 mL | 1.3931 mL |
Pyronin B Related Classifications
HY-D1543 Related Classifications
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