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Cat. No.: HY-129448

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RO4583298

RO4583298 is a potent, orally active dual antagonist of NK₁ (human and gerbil)/NK₃ (human, cynomolgus monkey, gerbil and guinea-pig). RO4583298 inhibits senktide-induced potentiation of spontaneous activity of dopaminergic neurons. RO4583298 can block gerbil foot tapping response and inhibits mouse tail whips.

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CAS No.: 825643-56-9
화학식: C₃₀H₃₀F₇N₃O₃
분자량:613.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

RO4583298 Chemical Structure

CAS No.: 825643-56-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Neurokinin Receptor Isoforms :

Chemical Information

CAS No. 825643-56-9
분자량 613.57
화학식 C₃₀H₃₀F₇N₃O₃
SMILES

O=C(N(C1=C(C2=CC=C(F)C=C2C)C=C(N3[C@H](CO)[C@@H](O)CC3)N=C1)C)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Malherbe, P., et al., (2011). Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors. British journal of pharmacology, 162(4), 929-946. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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RO4583298

All Neurokinin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

RO4583298 Related Classifications

HY-129448 Related Classifications