Rooperol
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects.
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- CAS No.: 83644-00-2
- 화학식: C17H14O4
- 분자량:282.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 83644-00-2
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분자량 282.29
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화학식 C17H14O4
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SMILES
OC1=CC=C(C=C1O)/C=C/CC#CC2=CC=C(C(O)=C2)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Boukes G J, et al. Rooperol as an antioxidant and its role in the innate immune system: An in vitro study[J]. Journal of ethnopharmacology, 2012, 144(3): 692-699. [Content Brief]
[2]. Kabanda M M. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study[J]. Chemical research in toxicology, 2012, 25(10): 2153-2166. [Content Brief]
[3]. Guzdek A, et al. Rooperol, an inhibitor of cytokine synthesis, decreases the respiratory burst in human and rat leukocytes and macrophages[J]. Mediators of Inflammation, 1997, 6(1): 53-57. [Content Brief]
[4]. Ali Azouaou S, et al. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells[J]. Investigational New Drugs, 2015, 33: 64-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rooperol Related Classifications
HY-119666 Related Classifications
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