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Cat. No.: HY-172438

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Setomagpran

Setomagpran is an antagonist of Mas-related G protein-coupled receptor X2 (MRGPRX2). Setomagpran inhibits MRGPRX2-mediated Gαq protein recruitment signaling, exhibiting an inhibitory IC₅₀ of 236 nM in HEK293T cells transiently expressing MRGPRX2. Setomagpran can be used in research on MRGPR-mediated diseases, such as inflammatory disorders.

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CAS No.: 2991434-57-0
화학식: C₂₂H₁₉Cl₂F₆N₅O
분자량:554.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Setomagpran Chemical Structure

CAS No.: 2991434-57-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Setomagpran (compound 15) inhibits activity in HEK293T cells transiently expressing MRGPRX2 with IC₅₀ = 236 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2991434-57-0
분자량 554.32
화학식 C₂₂H₁₉Cl₂F₆N₅O
SMILES

FC(F)(F)C1=NC(C=CC(Cl)=C2)=C2C(N[C@@H]3C[C@@H](CCC3)NC(C4=CN(N=C4Cl)CC(F)(F)F)=O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zheng S, et al. 1,3‑cyclohexanediamine derivatives as MRGPRX2 inhibitors, preparation method therefor and pharmaceutical use thereof. WO2026194690, 2026.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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