country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-137922

Copy Link Print Information

SHS4121705

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC₅₀ of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2379550-82-8
화학식: C₁₁H₆F₃N₅O₃
분자량:313.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SHS4121705 Chemical Structure

CAS No.: 2379550-82-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC₅₀ of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L6	EC₅₀	4.3 μM Compound: 12i; SHS4121705	Induction of mitochondrial uncoupling in rat L6 cells assessed as increase in oxygen consumption rate incubated for 90 mins by Seahorse XF analyzer based assay Induction of mitochondrial uncoupling in rat L6 cells assessed as increase in oxygen consumption rate incubated for 90 mins by Seahorse XF analyzer based assay	[PMID: 32392051]
L6	EC₅₀	4.3 μM Compound: SHS4121705	Induction of mitochondrial uncoupled respiration in rat L6 myoblasts assessed as increase in oxygen consumption rate measured by Agilent Seahorse XF analyzer Induction of mitochondrial uncoupled respiration in rat L6 myoblasts assessed as increase in oxygen consumption rate measured by Agilent Seahorse XF analyzer	[PMID: 35907607]
MCF7	EC₅₀	4.3 μM Compound: SHS4121705	Antiproliferative activity against human MCF7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 33569941]

In Vivo

SHS4121705 (25 mg/kg, orally, for 21 days) decreases liver triglyceride levels and improves liver markers in STAM mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2379550-82-8
분자량 313.19
화학식 C₁₁H₆F₃N₅O₃
SMILES

O=C1N=C2C(N=C1NC3=CC=C(OC(F)(F)F)C=C3)=NON2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Salamoun JM, et al. 6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Jun 11;63(11):6203-6224. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SHS4121705

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SHS4121705 Related Classifications

HY-137922 Related Classifications