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Cat. No.: HY-117918

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ST-1892

ST-1892 (compound 14) is a highly potent FXR agonist (EC₅₀=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation.

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CAS No.: 1409411-32-0
화학식: C₁₆H₁₂N₂O₃
분자량:280.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ST-1892 Chemical Structure

CAS No.: 1409411-32-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

ST-1892 (compound 14) is a highly potent FXR agonist (EC₅₀=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.0072 μM Compound: 14	Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay	[PMID: 25934227]

Chemical Information

CAS No. 1409411-32-0
분자량 280.28
화학식 C₁₆H₁₂N₂O₃
SMILES

O=C(C1=CC=CC(C2=NC(C3=CC=CC=C3C)=NO2)=C1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Flesch D, et al. Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties[J]. Bioorganic & medicinal chemistry, 2015, 23(13): 3490-3498. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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