country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-11085

Copy Link Print Information

T-226296

T-226296 is an oral active and selective melanin-concentrating hormone receptor antagonist with the IC₅₀ values of 5.5 nM and 8.6 nM for human SLC-1 and rat SLC-1, respectively. T-226296 can be used for study of obesity and insulin resistance.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 331758-35-1
화학식: C₂₆H₂₇FN₂O
분자량:402.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

T-226296 Chemical Structure

CAS No.: 331758-35-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	14 nM Compound: 1h	Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting	[PMID: 21856163]
CHO	IC₅₀	24 nM Compound: 1h	Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting	[PMID: 21856163]
CHO	IC₅₀	43 nM Compound: 1h	Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting	[PMID: 21856163]
CHO	IC₅₀	5.5 nM Compound: 1, T-226296	Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay	[PMID: 21190859]
CHO	IC₅₀	5.5 nM Compound: 7	Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells	[PMID: 15267235]
CHO	IC₅₀	5.5 nM Compound: T-226296	Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells	[PMID: 21975069]
HEK293	IC₅₀	5.5 nM Compound: I, T-226296	Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay	[PMID: 19773162]
IMR-32	IC₅₀	872 nM Compound: T-226296 (-)	Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader	[PMID: 15341943]

Chemical Information

CAS No. 331758-35-1
분자량 402.50
화학식 C₂₆H₂₇FN₂O
SMILES

O=C(C1=CC=C(C2=CC=C(C=C2)F)C=C1)NC3=CC=C(CC(CC4)CN(C)C)C4=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takekawa S, et al. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur J Pharmacol. 2002;438(3):129-135. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기