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Cat. No.: HY-126489

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Tetromycin B

Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC₅₀=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC₅₀s=71.77 and 20.2 μM, respectively).

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CAS No.: 180027-84-3
화학식: C₃₄H₄₆O₅
분자량:534.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tetromycin B Chemical Structure

CAS No.: 180027-84-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	IC₅₀	>30 μM Compound: 11	Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]
SW-620	IC₅₀	>30 μM Compound: 11	Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay Cytotoxicity against human SW-620 cells and measured after 48 hrs by MTT assay	[PMID: 35640100]

Chemical Information

CAS No. 180027-84-3
분자량 534.73
화학식 C₃₄H₄₆O₅
SMILES

CC1=C[C@]2([C@@]([H])([C@H](CC[C@@H]2O)C)[C@@](C)([C@@]1(/C(C)=C/CC/C(C)=C/[C@]3([C@]4(C[C@H](C(C)=C3)C)OC5=O)C)[H])C(C5=C4O)=O)[H]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pimentel-Elardo, et al. New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities. Mar. Drugs 9(10), 1682-1697 (2011).

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
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Tetromycin B

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Tetromycin B Related Classifications

HY-126489 Related Classifications