country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-180403

Copy Link Print Information

TLX agonist 3

TLX agonist 3 is a potent and selective tailless homolog (TLX, NR2E1) agonist with an EC₅₀ of 0.25 μM and a K_d of 1.6 μM). TLX agonist 3 shows high selectivity over related nuclear receptors, and promotes TLX oligomerization with an EC₅₀ of 5.0 μM. TLX agonist 3 can be used for the research of neurodegenerative diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3032232-47-3
화학식: C₂₅H₂₃F₃N₄O₂
분자량:468.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

TLX agonist 3 Chemical Structure

CAS No.: 3032232-47-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

TLX

0.25 μM (EC₅₀)

TLX

1.6 μM (Kd)

In Vitro

TLX agonist 3 (compound 10) (2.5-20 μM; 22 h) enhances TLX oligomerization in a concentration-dependent manner in homogeneous time-resolved fluorescence resonance energy transfer\n(HTRF)-based assay^[1].
TLX agonist 3 activates full-length human TLX in HEK293 cells with an EC₅₀ of 0.7 μM^[1].
TLX agonist 3 (3 µM; 8 h) induces SIRT1 expression without altering TLX levels in T98G human astrocyte cells cells^[1].
TLX agonist 3 (10 µM; 0-60 min) shows favorable microsomal stability (t_1/2 = 142 min) in rat liver microsomes^[1].
TLX agonist 3 (up to 10 µM; 24 h) shows no pronounced cytotoxic effects in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

T98G human astrocyte cells
Concentration:

3 μM
Incubation Time:

8 h
Result:

Induced expression of the TLX-regulated gene SIRT1 but did not alter TLX levels.

Chemical Information

CAS No. 3032232-47-3
분자량 468.48
화학식 C₂₅H₂₃F₃N₄O₂
SMILES

O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2C=NC(=C2)C)C=3C=C(N=C4C=CC=CC43)OCCCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Faudone G, et al. Design of a Potent TLX Agonist by Rational Fragment Fusion. J Med Chem. 2022;65(3):2288-2296. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기