Ulevostinag
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research.
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- CAS No.: 2082743-96-0
- 화학식: C20H22F2N10O9P2S2
- 분자량:710.52
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Ulevostinag (MK-1454) (4 μg for intratumorally on day 0, 3 and 7) results in complete tumor regression and enhances the efficacy of anti-PD1 therapy in MC38 and B16F10 tumor mice model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MC38 colon adenocarcinoma tumor-bearing mice[1]
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Dosage:5 μg, 20 μg
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Administration:intratumorally
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Result:Regressed the injected (right) tumors and was detected in injected and noninjected tumors as well as plasma when dosed at 20 μg.
Elevated IFN-β and proinflammatory cytokines IL-6 and TNF-α in injected tumors.
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Animal Model:MC38 and B16F10 tumor mice model[1]
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Dosage:4 μg
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Administration:intratumorally
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Result:Improved tumor growth inhibition with 7 CRs out of 10 mice over 28 days.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2082743-96-0
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Appearance Solid
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분자량 710.52
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화학식 C20H22F2N10O9P2S2
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Color White to off-white
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SMILES
F[C@H]1[C@](O[P@](S)(OC[C@](O[C@](N2C3=NC=NC(N)=C3N=C2)([H])[C@H]4F)([H])[C@@]4([H])O5)=O)([H])[C@@](N6C(NC(N)=NC7=O)=C7N=C6)([H])O[C@]1([H])CO[P@]5(S)=O
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Synonyms
MK-1454
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zawit M, et al. Current status of intralesional agents in treatment of malignant melanoma. Ann Transl Med. 2021 Jun;9(12):1038. [Content Brief]
[2]. Gogoi H, et al. The Age of Cyclic Dinucleotide Vaccine Adjuvants. Vaccines (Basel). 2020 Aug 13;8(3):453. [Content Brief]
[3]. Chang W, et al. Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer. J Med Chem. 2022 Apr 14;65(7):5675-5689. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ulevostinag Related Classifications
HY-139586 Related Classifications
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