VU0155041 sodium
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).
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- CAS No.: 1259372-69-4
- 화학식: C14H14Cl2NNaO3
- 분자량:338.16
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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mGluR4 693 nM (EC50) |
VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
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Dosage:31, 93 nmol
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Administration:I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
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Result:Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
Chemical Information
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CAS No. 1259372-69-4
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분자량 338.16
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화학식 C14H14Cl2NNaO3
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SMILES
O=C([C@H](CCCC1)[C@H]1C(O[Na])=O)NC2=CC(Cl)=CC(Cl)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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