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Cat. No.: HY-184156

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WSL017

WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis.

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화학식: C₁₇H₁₉NOS
분자량:285.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WSL017 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

WSL017 is a cytochrome bd oxidase inhibitor with antibacterial activity against Mycobacterium tuberculosis. WSL017 can be used for the research of tuberculosis^[1].

In Vitro

WSL017 (0.001-100 µM) competitively inhibits Mycobacterium tuberculosis cytochrome bd (Mtbd) in proteoliposomes with an IC₅₀ of 1.4 µM by binding to the quinol-binding site^[1].
WSL017 (0.001-100 µM) competitively inhibits Escherichia coli cytochrome bd (Ecbd) in proteoliposomes with an IC₅₀ of 1.7 µM by binding to the quinol-binding site^[1].
WSL017 (3 µM) does not inhibit Caldalkalibacillus thermarum type 2 NADH dehydrogenase (NDH2) activity, confirming its specific action on cytochrome bd oxidases^[1].
WSL017 (100 µM) binds to the quinol oxidation site of dimeric Escherichia coli cytochrome bd (Ecbd) via hydrophobic interactions, stabilizing the Q-loop in a closed state to inhibit enzyme activity^[1].
WSL017 (25 µM; 7 days) significantly impairs the growth of Mycobacterium tuberculosis H37ra cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Mycobacterium tuberculosis H37ra cells
Concentration:

25 µM
Incubation Time:

7 days
Result:

Reduced growth to approximately 50% relative to control.
Significantly impaired the growth of Mycobacterium tuberculosis H37ra cells.

Related Protocols :

Chemical Information

분자량 285.40
화학식 C₁₇H₁₉NOS
SMILES

CCC(NC1=CC=C(SC2=CC(C)=CC=C2C)C=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tijn T. van der Velden, et al. Discovery of a novel chemotype targeting Mycobacterium tuberculosis cytochrome bd through rapid screening and structural elucidation. bioRxiv. 2026.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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