L-Isoleucine-¹⁵N,d₁₀

Name: L-Isoleucine- 15 N,d 10
Brand: MedChemExpress
SKU: HY-N0771S7
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0771S7 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Isoleucine-¹⁵N,d₁₀ is the deuterium and ¹⁵N-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

For research use only. We do not sell to patients.

L-Isoleucine-<sup>15</sup>N,d<sub>10</sub> Chemical Structure

L-Isoleucine-¹⁵N,d₁₀ Chemical Structure

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 495	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 495	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Isoleucine-¹⁵N,d₁₀:

L-Isoleucine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Isoleucine-¹⁵N,d₁₀ is the deuterium and ¹⁵N-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

142.23

Formula

C₆H₃D₁₀¹⁵NO₂

Appearance

Solid

Color

White to off-white

SMILES

[15NH2][C@]([C@@]([2H])(C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (175.77 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0309 mL	35.1543 mL	70.3087 mL
5 mM	1.4062 mL	7.0309 mL	14.0617 mL
10 mM	0.7031 mL	3.5154 mL	7.0309 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (87.89 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (256 KB) HNMR (261 KB) MS (181 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.0309 mL	35.1543 mL	70.3087 mL	175.7716 mL
	5 mM	1.4062 mL	7.0309 mL	14.0617 mL	35.1543 mL
	10 mM	0.7031 mL	3.5154 mL	7.0309 mL	17.5772 mL
	15 mM	0.4687 mL	2.3436 mL	4.6872 mL	11.7181 mL
	20 mM	0.3515 mL	1.7577 mL	3.5154 mL	8.7886 mL
	25 mM	0.2812 mL	1.4062 mL	2.8123 mL	7.0309 mL
	30 mM	0.2344 mL	1.1718 mL	2.3436 mL	5.8591 mL
	40 mM	0.1758 mL	0.8789 mL	1.7577 mL	4.3943 mL
	50 mM	0.1406 mL	0.7031 mL	1.4062 mL	3.5154 mL
	60 mM	0.1172 mL	0.5859 mL	1.1718 mL	2.9295 mL
	80 mM	0.0879 mL	0.4394 mL	0.8789 mL	2.1971 mL
	100 mM	0.0703 mL	0.3515 mL	0.7031 mL	1.7577 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.