Lagociclovir valactate
Lagociclovir valactate is a prodrug of Lagociclovir (HY-14844). Lagociclovir valactate is an orally active anti-HBV agent.
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- CAS No.: 1001670-19-4
- Formule: C19H27FN6O6
- Masse moléculaire:454.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
HBV[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Woodchucks with chronic WHV infection[1]
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Dosage:20 or 60 mg/kg
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Administration:Oral, daily for 10 weeks
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Result:Reduced WHV viremia effectively and maintained WHV DNA at a very low level.
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Animal Model:Woodchucks[1]
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Dosage:10 or 40 mg/kg
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Administration:Oral (Pharmacokinetic Analysis)
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Result:Average pharmacokinetic parameters for Lagociclovir after oral administration of Lagociclovir valactate to healthy and chronically WHV infected woodchucks[1]
Pharmacokinetic parameter for Lagociclovir Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 10 mg/kg Healthy woodchucks (n = 4) receiving Lagociclovir valactate at 40 mg/kg WHV-infected woodchucks (n = 14) receiving Lagociclovir valactate at 60 mg/kg Cmax (μM) 0.54 ± 0.14 2.10 ± 1.5 3.50 ± 1.9 Tmax (h) 4.10 ± 1.0 3.30 ± 1.5 2.90 ± 1.1 AUC0-∞ (μM • h/liter) 5.15 ± 1.0 10.50 ± 4.2 20.1 ± 11.3 t1/2 (h) 5.44 ± 1.2 4.20 ± 1.6 4.7 ± 0.8
Chemical Information
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CAS No. 1001670-19-4
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Masse moléculaire 454.45
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Formule C19H27FN6O6
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SMILES
O=C1C2=C(NC(N)=N1)N([C@](C[C@@H]3F)(C)O[C@@H]3COC([C@H](C)OC([C@@H](N)C(C)C)=O)=O)C=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lagociclovir valactate Related Classifications
HY-107026 Related Classifications
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