Lamivudine salicylate
Based on 19 publication(s) in Google Scholar
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine salicylate can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
For research use only. We do not sell to patients.
- CAS No.: 173522-96-8
- Formula: C15H17N3O6S
- Molecular Weight:367.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lamivudine salicylate
More- Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
- Cell. 2025 Sep 4;188(18):4896-4912.e19. [Abstract]
- Nat Aging. 2026 Feb;6(2):414-429. [Abstract]
- Phytother Res. 2021 Aug;35(8):4555-4566. [Abstract]
- Aging Cell. 2026 Jan;25(1):e70350. [Abstract]
- Eur J Pharmacol. 2025 Oct 15:1005:178108. [Abstract]
- Int J Mol Sci. 2025 Dec 27;27(1):300. [Abstract]
- Molecules. 2022 May 18;27(10):3223. [Abstract]
- Mol Med Rep. 2025 Jul;32(1):203. [Abstract]
- Int J Antimicrob Agents. 2019 Dec;54(6):814-819. [Abstract]
- J Cell Mol Med. 2021 Sep;25(17):8490-8503. [Abstract]
- ACS Infect Dis. 2025 Oct 30. [Abstract]
- Biomedicines. 2022 Jan 26;10(2):268. [Abstract]
- ASN Neuro. 2026;18(1):2647877. [Abstract]
- Virol J. 2025 Oct 27;22(1):342. [Abstract]
- J Med Virol. 2026 Jan;98(1):e70764. [Abstract]
- J Clin Virol. 2025 Apr:177:105781. [Abstract]
- Front Oncol. 2024 Dec 19:14:1501981. [Abstract]
- Virus Res. 2019 Oct 2:271:197677. [Abstract]
Customer Validation & Images
-
Cell Imaging/Staining
-
Bio/Physico-chemical Assay
-
WB
-
Bio/Physico-chemical Assay
-
Histological Imaging/Staining
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 173522-96-8
-
Molecular Weight 367.38
-
Formula C15H17N3O6S
-
SMILES
OC[C@H]1SC[C@@H](N2C(N=C(N)C=C2)=O)O1.OC3=C(C(O)=O)C=CC=C3
-
Synonyms
BCH-189 salicylate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (19)
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
Inhibition of long interspersed nuclear element-1 by nucleoside reverse transcriptase inhibitors attenuates vascular calcification. [Abstract]2025 Oct 1;10(1):321. PMID: 41027876
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
VSMCs were treated with Pi and NRTIs (Lamivudine, 1, 5, 10, or 50 μM), followed by Alizarin Red staining.
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
VSMCs treated with Pi and NRTIs (Lamivudine, 1, 5, 10, or 50 μM). followed by calcium content.
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
Western blot analysis expression of Runx2, OPN, Smoothelin, SM22α, and LINE1-ORF1 in VSMCs treated with Pi and NRTIs.
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
Serum creatinine levels in CKD mice treated with NRTIs (Lamivudine, 1 mg/kg, administered daily intraperitoneal injections).
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
NRTIs (Lamivudine, 1 mg/kg, administered daily intraperitoneal injections). Aortic cross-sections from CKD mice or VitD3-overloaded mice were stained using Von Kossa, with n = 3 per group; scale bar = 100 μm.
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
NRTIs (Lamivudine, 1 mg/kg, administered daily intraperitoneal injections). Calcium content analysis of aortas from CKD mice or VitD3-overloaded mice (n = 5 per group).
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
NRTIs (Lamivudine, 1 mg/kg, administered daily intraperitoneal injections). Immunohistochemical staining of Runx2 and LINE1-ORF1 from CKD mice or VitD3-overloaded mice (n = 3 per group); scale = 50 μm.
Lamivudine salicylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]
NRTIs (Lamivudine, 1 mg/kg, administered daily intraperitoneal injections). Osteogenic and contractile phenotypic markers, as well as LINE1-ORF1, were analyzed through Western blot and quantitative in CKD mice (n = 3 per group).
-
Cell
Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo. [Abstract]2025 Sep 4;188(18):4896-4912.e19. PMID: 40645177 -
Nat Aging
2026 Feb;6(2):414-429. PMID: 41571992 -
Phytother Res
Anti-hepatitis B virus activity and hepatoprotective effect of des(rhamnosyl) verbascoside from Lindernia ruellioides in vitro. [Abstract]2021 Aug;35(8):4555-4566. PMID: 34146352 -
Aging Cell
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging. [Abstract]2026 Jan;25(1):e70350. PMID: 41480826 -
Eur J Pharmacol
Astragalin inhibits hepatitis B virus through functional reconstitution of CD8+ T cells and a direct effect on HBV control. [Abstract]2025 Oct 15:1005:178108. PMID: 40886877 -
Int J Mol Sci
Triterpenoids CDDO and CDDO-EA Inhibit the Replication of Hepatitis B Virus by Modulating Nucleocapsid Assembly. [Abstract]2025 Dec 27;27(1):300. PMID: 41516181 -
Molecules
(-)-Lariciresinol Isolated from the Roots of Isatis indigotica Fortune ex Lindl. Inhibits Hepatitis B Virus by Regulating Viral Transcription. [Abstract]2022 May 18;27(10):3223. PMID: 35630700 -
Mol Med Rep
Identification of metabolites associated with capecitabine‑induced hand‑foot syndrome using untargeted metabolomics in patients with cancer. [Abstract]2025 Jul;32(1):203. PMID: 40377002 -
Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744 -
J Cell Mol Med
Lamivudine improves cognitive decline in SAMP8 mice: Integrating in vivo pharmacological evaluation and network pharmacology. [Abstract]2021 Sep;25(17):8490-8503. PMID: 34374199 -
ACS Infect Dis
Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights. [Abstract]2025 Oct 30. PMID: 41166549 -
Biomedicines
Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings. [Abstract]2022 Jan 26;10(2):268. PMID: 35203482 -
ASN Neuro
Exposure to Frontline Antiretroviral Dolutegravir Disrupts Oligodendrocyte Development Across Differentiation Stages. [Abstract]2026;18(1):2647877. PMID: 41904696 -
Virol J
Sophora alopecuroides biflavones glycoside, isolated from Sophora alopecuroides, inhibits the secretion of hepatitis B virus surface antigen through direct interaction with its antigenic loop domain. [Abstract]2025 Oct 27;22(1):342. PMID: 41146264 -
J Med Virol
Dynamics of Serum Hepatitis B Virus Nucleic Acids in Patients With Chronic Hepatitis B After Stopping Nucleos(t)ide Analogs Reveal Delayed Rebound of Hepatitis B Virus RNA. [Abstract]2026 Jan;98(1):e70764. PMID: 41439722 -
J Clin Virol
2025 Apr:177:105781. PMID: 40120569 -
Front Oncol
Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer. [Abstract]2024 Dec 19:14:1501981. PMID: 39791120 -
Virus Res
2019 Oct 2:271:197677. PMID: 31376401
Purity & Documentation
References
[1]. Li, Y.C., [A clinical study on lamivudine treatment for advanced schistosomisis with chronic B hepatits]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2013. 25(5): p. 548-9, 551. [Content Brief]
[2]. Zhang, C.E., et al., [Effects of lamivudine on growth of intestinal characteristic bacteria by microcalorimetry in vitro]. Yao Xue Xue Bao, 2013. 48(10): p. 1590-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lamivudine salicylate Related Classifications
HY-B0250A Related Classifications
Powered by Bioz