Leupeptin hemisulfate (Standard)
Leupeptin hemisulfate (Standard) is the analytical standard of Leupeptin hemisulfate (HY-18234A ). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 103476-89-7
- Formula: C20H38N6O4.1/2H2SO4
- Molecular Weight:475.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-18234A
Leupeptin hemisulfateProtease Inhibitor -
HY-B0496
PMSFCathepsin Inhibitor -
HY-P0017
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HY-12821
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HY-100229
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HY-15282
E-64Cysteine Peptidase Inhibitor -
HY-D0843
N-EthylmaleimideCysteine Residues Modifier -
HY-P0018
PepstatinAspartic Protease Inhibitor -
HY-B0190A
Nafamostat mesylateSerine Protease Inhibitor -
HY-100350
CA-074 methyl esterCathepsin B Inhibitor -
HY-E70203
Recombinant aprotininSerine Protease Inhibitor -
HY-B0445
NAD+Endogenous Metabolite
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 103476-89-7
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Molecular Weight 475.59
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Formula C20H38N6O4.1/2H2SO4
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SMILES
O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N.[0.5H2SO4]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sharma A, et al. Leupeptin maintains redox homeostasis via targeting ROS-autophagy-inflammatory axis in LPS-stimulated macrophages and cytokines dichotomy in Con-A challenged lymphocyte. Peptides. 2023 Oct;168:171066. [Content Brief]
[2]. Hozumi M, et al. Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes. Cancer Res. 1972 Aug;32(8):1725-8. [Content Brief]
[3]. Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42. [Content Brief]
[4]. Billinger E, et al. Inhibition properties of free and conjugated leupeptin analogues. FEBS open bio. 2020 Dec;10(12):2605-2615. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leupeptin hemisulfate (Standard) Related Classifications
HY-18234AR Related Classifications
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Keywords
- Leupeptin hemisulfate (Standard)
- 103476-89-7
- Reference Standards
- Ser/Thr Protease
- Cathepsin
- Autophagy
- SARS-CoV
- Atg8/LC3
- NO Synthase
- COX
- p62
- Arginase
- PTEN
- NF-κB
- PI3K
- Akt
- p38 MAPK
- ERK
- Reactive Oxygen Species (ROS)
- kallikrein
- cathepsins B
- L
- and H
- LPS-induced mitochondrial membrane potential hyperpolarization
- mouse skin
- papain
- chymotrypsin
- mouse hepatocytes
- trypsin
- beclin 1+/- mouse liver
- plasmin
- Inhibitor
- inhibitor
- inhibit