2. TGF-beta/Smad
  3. TGF-β Receptor
  4. M4K2308

M4K2308 is a selective ether-linked inhibitor of ALK2 with an IC50 of 2 nM. M4K2308 exhibits exceptional selectivity for ALK2 over ALK5 (IC50 of 224 nM). M4K2308 has the potential for the study of diffuse intrinsic pontine glioma (DIPG) research.

For research use only. We do not sell to patients.

M4K2308 Chemical Structure

M4K2308 Chemical Structure

CAS No. : 3034840-18-8

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M4K2308 Related Antibodies

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

M4K2308 is a selective ether-linked inhibitor of ALK2 with an IC50 of 2 nM. M4K2308 exhibits exceptional selectivity for ALK2 over ALK5 (IC50 of 224 nM). M4K2308 has the potential for the study of diffuse intrinsic pontine glioma (DIPG) research[1].

IC50 & Target[1]

ALK2

2 nM (IC50)

ALK5

224 nM (IC50)

Molecular Weight

447.53

Formula

C26H29N3O4
CAS No.
SMILES

COC(C=C1C2=C3C(C4=CC=C(N5CCNCC5)C=C4OCC3)=CN=C2)=C(C(OC)=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M4K2308 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K23083034840-18-8TGF-β ReceptorTransforming growth factor beta receptorsALK2 inhibitorether-linkeddiffuse intrinsic pontine gliomaInhibitorinhibitorinhibit

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