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Cat. No.: HY-P12279

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MAAAHR

MAAAHR is a neuroprotective agent. MAAAHR is isolated and purified from C-phycocyanin of Spirulina platensis. MAAAHR induces antioxidant gene expression through activating the Nrf2 signaling pathway. MAAAHR inhibits excessive Autophagy by reducing the expression of proteins such as α-Syn and Parkin. MAAAHR inhibits Apoptosis. MAAAHR scavenges excessive ROS, enhances SOD, CAT, and GSH-Px activities, and reduces protein carbonyl content. MAAAHR inhibits Acetylcholinesterase. MAAAHR protects zebrafish against MPTP (HY-15608)-induced dopaminergic neuronal and neurovascular loss and alleviates motor impairment. MAAAHR can be used for research on Parkinson's disease.

For research use only. We do not sell to patients.

Formula: C₂₆H₄₅N₁₁O₇S
Molecular Weight:655.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAAAHR Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

AChE	α-synuclein

All α-synuclein Isoforms :

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

MAAAHR exhibits antioxidant, pro-autophagic, and anti-apoptotic functions^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MAAAHR (12.5-50 μg/mL) exhibits neuroprotective activity against MPTP-induced Parkinson's disease-like pathology in zebrafish by protecting DA neurons and neural vasculature, improving locomotor capacity, and modulating oxidative stress, autophagy, and apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild-type AB strain and transgenic vmat2:GFP and fli1:GFP strains (embryos)^[1]
Dosage:

12.5, 25, and 50 μg mL−1
Administration:

Co-exposure with 70 μM MPTP in E3 culture solution; daily; from 24 hpf to 96 hpf (continued until 144 hpf for behavioral and gene expression assays)
Result:

Completely reversed the MPTP-induced degeneration of DA neurons in a dose-dependent manner.
Reversed the loss of vasculature and disorganized vasculature caused by MPTP.
Significantly increased the average movement speed and total distance traveled compared to the MPTP model group.
Reduced elevated ROS levels, increased SOD, CAT, and GSH-Px activities, and decreased protein carbonyl content, with the highest concentration returning these indicators to normal levels.
Effectively inhibited MPTP-induced cell apoptosis in a concentration-dependent manner.
High doses dose-dependently inhibited AChE activity.
Reversed the MPTP-induced decrease in nrf2, gclc, gclm, ho-1, and nqo-1, and the increase in keap1.
Reversed the MPTP-induced increases in autophagy-related genes (α-syn, parkin, beclin1, atg5, map1lc3b, atg3) and apoptosis-related genes (caspase-1, caspase-3, caspase-8, caspase-9, bax).

Chemical Information

Molecular Weight 655.77
Formula C₂₆H₄₅N₁₁O₇S
SMILES

O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Sequence

Met-Ala-Ala-Ala-His-Arg
Sequence Shortening

MAAAHR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu FH, et al. The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 2023 Jul 03;14(13):6157-6171.

[2]. Ramos V, et al. Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?. Biomolecules. 2023 Sep 25;13(10):1444.

[3]. Li Z, et al. Food-Derived Peptides: Beneficial CNS Effects and Cross-BBB Transmission Strategies. Journal of agricultural and food chemistry. 2023 Dec 27;71(51):20453-20478.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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MAAAHR

All α-synuclein Isoforms

All Glutathione Peroxidase Isoforms

All Cholinesterase (ChE) Isoforms