1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MC-GGFG-DX8951

MC-GGFG-DX8951 

Cat. No.: HY-114233 Purity: 99.71%
Handling Instructions

MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker.

For research use only. We do not sell to patients.

MC-GGFG-DX8951 Chemical Structure

MC-GGFG-DX8951 Chemical Structure

CAS No. : 1600418-29-8

Size Price Stock Quantity
5 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 7500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 13500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker[1].

IC50 & Target

Camptothecins

 

Molecular Weight

946.97

Formula

C₄₉H₅₁FN₈O₁₁

CAS No.

1600418-29-8

SMILES

O=C1OCC2=C(C=C(C3=NC4=CC(F)=C(C)C(CC[[email protected]@H]5NC(CNC([[email protected]@H](NC(CNC(CNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=C4C5=C3C8)N8C2=O)[[email protected]@]1(O)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (105.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0560 mL 5.2800 mL 10.5600 mL
5 mM 0.2112 mL 1.0560 mL 2.1120 mL
10 mM 0.1056 mL 0.5280 mL 1.0560 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MC-GGFG-DX8951Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product name:
MC-GGFG-DX8951
Cat. No.:
HY-114233
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