2. Academic Validation
  3. Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905

Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905

  • J Antibiot (Tokyo). 2010 Apr;63(4):183-6. doi: 10.1038/ja.2010.14.
Nobuhiro Koyama 1,  Shigenobu Kojima,  Kenichi Nonaka,  Rokuro Masuma,  Makoto Matsumoto,  Satoshi Omura,  Hiroshi Tomoda
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
PMID: 20186169 DOI: 10.1038/ja.2010.14
Abstract

Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a Fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various Microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.

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