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Cat. No.: HY-156069

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Methylspinazarin

Methylspinazarin is a potent inhibitor of catechol O-methyltransferase (COMT, IC₅₀ = 0.8 μg/ml) that can be isolated from Streptomyces. Methylspinazarin is selective for COMT over tyrosine hydroxylase.

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CAS No.: 41768-12-1

Formula: C₁₁H₈O₆

Molecular Weight:236.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Methylspinazarin Chemical Structure

CAS No.: 41768-12-1

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Biological Activity

Description

Methylspinazarin is a potent inhibitor of catechol O-methyltransferase (COMT, IC₅₀ = 0.8 μg/ml) that can be isolated from Streptomyces. Methylspinazarin is selective for COMT over tyrosine hydroxylase^[1].

Chemical Information

CAS No. 41768-12-1

Molecular Weight 236.18

Formula C₁₁H₈O₆

SMILES

O=C1C(O)=C(C(C2=C(C(C)=CC(O)=C12)O)=O)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. H Chimura, et al. Letter: Methylspinazarin and dihydromethylspinazarin, catechol-O-methyl transferase inhibitors produced by Streptomyces. J Antibiot (Tokyo). 1973 Feb;26(2):112-4. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Methylspinazarin Related Classifications

HY-156069 Related Classifications

Metabolic Enzyme/Protease Neuronal Signaling

COMT

Disease Areas

Cancer Neurological, Eye or Ear Disease

Neurological Disease Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

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Keywords

Methylspinazarin
41768-12-1
COMT
Inhibitor
inhibitor
inhibit

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