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Cat. No.: HY-130451

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Misakimycin

Misakimycin is a naphthoquinone compound. Misakimycin exhibits cytotoxicity against human melanoma, breast cancer and ovarian cancer cells. Misakimycin can be found in strains of the genus Pyrenochaetopsis (strain MSX63693). Misakimycin can be used in research related to melanoma, breast cancer and ovarian cancer.

For research use only. We do not sell to patients.

CAS No.: 91776-49-7
Formula: C₁₃H₁₂O₅
Molecular Weight:248.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Misakimycin Chemical Structure

CAS No.: 91776-49-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	15 μM Compound: 6	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]
MDA-MB-435	IC₅₀	3.2 μM Compound: 6	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]
OVCAR-3	IC₅₀	9.6 μM Compound: 6	Cytotoxicity against human OVCAR-3 cells after 72 hrs by Cell Titer-Blue cell viability assay Cytotoxicity against human OVCAR-3 cells after 72 hrs by Cell Titer-Blue cell viability assay	[PMID: 33006889]

In Vitro

Misakimycin (72 h) inhibits the growth of human melanoma MDA-MB-435 cells, human breast cancer MDA-MB-231 cells, and human ovarian cancer OVCAR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-435, MDA-MB-231, OVCAR3
Concentration:

/
Incubation Time:

72 h
Result:

Had an IC₅₀ of 3.2 μM for MDA-MB-435 cells, 15 μM for MDA-MB-231 cells and 9.6 μM for OVCAR3 cells.

Chemical Information

CAS No. 91776-49-7
Molecular Weight 248.23
Formula C₁₃H₁₂O₅
SMILES

O=C1C(OC)=CC(C2=C1C=C(OC)C(C)=C2O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Flores-Bocanegra L, et al. Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments. J Nat Prod. 2021;84(3):771-778. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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