2. Immunology/Inflammation
  3. Mesothelin
  4. Misitatug blivedotin

Misitatug blivedotin (RC88) is an antibody-drug conjugate (ADC) targeting mesothelin (MSLN). Misitatug blivedotin binds to mesothelin and exhibits dose‐dependent antitumor activity. Misitatug blivedotin can be used for the research of ovarian cancer, non-squamous non-small-cell lung carcinoma, cervical cancer.

For research use only. We do not sell to patients.

Misitatug blivedotin

Misitatug blivedotin Chemical Structure

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Misitatug blivedotin Related Antibodies

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Description

Misitatug blivedotin (RC88) is an antibody-drug conjugate (ADC) targeting mesothelin (MSLN). Misitatug blivedotin binds to mesothelin and exhibits dose‐dependent antitumor activity. Misitatug blivedotin can be used for the research of ovarian cancer, non-squamous non-small-cell lung carcinoma, cervical cancer[1][2].

In Vitro

RC88 effectively blocks CA125 from binding to MSLN[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Misitatug blivedotin Related Antibodies
Parmacokinetics
Species Dose Route CL
Mice[3] 0.75; 1.5; 3 mg/kg i.v. 0.527 mL/h/kg
Cynomolgus Monkey[3] 0.5; 1.5; 5 mg/kg i.v. 0.556 mL/h/kg
In Vivo

Misitatug blivedotin (0.7-3 mg/kg; i.v.; Q1W × 1 or Q1W × 3) exhibits dose‐dependent antitumor activity in female Balb/c nude mice implanted subcutaneously with 3 million OVCAR3‐MSLN‐3# or H292‐MSLN‐9C8 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (female; ages 4–5 weeks; implanted subcutaneously with 3 million OVCAR3‐MSLN‐3# or H292‐MSLN‐9C8 cells for a xenograft model)[3]
Dosage: 0.7 mg/kg; 0.75 mg/kg; 1.5 mg/kg; 2.1 mg/kg; 3 mg/kg
Administration: i.v.; Q1W × 1 or Q1W × 3
Result: Had moderate activity at 0.75 mg/kg with single dosing, but tumor volume was less than the initial volume of tumors treated at 2.1 mg/kg until 11 days after dosing.
Significantly reduced the tumors 7 days after the first dosing at 1.5 and 3 mg/kg with multiple dosing.
Fully regressed tumors at 3 mg/kg for 10 days and at 1.5 mg/kg for 17 days, but the tumor continued to grow after three administrations at 0.75 mg/kg.
SMILES

[Misitatug blivedotin]
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Purity & Documentation
References
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Misitatug blivedotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Misitatug blivedotinRC88RC 88RC-88MesothelinMSLNcynomolgus monkeysocular toxicitymesothelinmice xenograft modelsnon-squamous non-small-cell lung carcinomaovarian cancermesothelin-positive tumorsmesothelin (MSLN)hematologic toxicitycervical cancerInhibitorinhibitorinhibit

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