Mitoflaxone
Based on 1 Customer Validation
Mitoflaxone (flavoneacetic acid) is a synthetic flavonoid compound with vascular targeting properties. Mitoflaxone exerts anti-proliferative effects on endothelial cells through a superoxide-dependent mechanism, this effect leads to changes in the permeability of tumor blood vessels, thereby exerting anti-tumor effects[1][2].
For research use only. We do not sell to patients.
- Purity : 99.82%
- CAS No.: 87626-55-9
- Formula: C17H12O4
- Molecular Weight:280.27
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 2008 | IC50 |
421.3 μM
Compound: FAA (Flavone -8-acetic acid)
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Direct cytotoxicity against the selected tumor cell line 2008 was determined especially on ovarian adenocarcinoma derived cells
Direct cytotoxicity against the selected tumor cell line 2008 was determined especially on ovarian adenocarcinoma derived cells
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[PMID: 12904070] |
| A549 | IC50 |
341.5 μM
Compound: 2, FAA
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Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
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[PMID: 24518295] |
| C13 | IC50 |
233.3 μM
Compound: FAA (Flavone -8-acetic acid)
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Direct cytotoxicity against the selected tumor cell line c13* was determined especially on ovarian adenocarcinoma derived cells
Direct cytotoxicity against the selected tumor cell line c13* was determined especially on ovarian adenocarcinoma derived cells
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[PMID: 12904070] |
| DLD-1 | IC50 |
>500 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit DLD1 cells
In vitro concentration required to inhibit DLD1 cells
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10.1016/0960-894X(94)85031-3 |
| HCT-8 | IC50 |
245 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit HCT18 cells
In vitro concentration required to inhibit HCT18 cells
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10.1016/0960-894X(94)85031-3 |
| HT-29 | IC50 |
2449.5 μM
Compound: 2, FAA
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Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
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[PMID: 24518295] |
| HT-29 | IC50 |
390 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit HT-29 cells
In vitro concentration required to inhibit HT-29 cells
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10.1016/0960-894X(94)85031-3 |
| K562 | IC50 |
310 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit K562 cells
In vitro concentration required to inhibit K562 cells
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10.1016/0960-894X(94)85031-3 |
| LoVo | IC50 |
378.3 μM
Compound: FAA (Flavone -8-acetic acid)
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In vitro cytotoxicity against the selected tumor cell line LoVoR arising from human colon adenocarcinoma was determined
In vitro cytotoxicity against the selected tumor cell line LoVoR arising from human colon adenocarcinoma was determined
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[PMID: 12904070] |
| LoVo | IC50 |
563.9 μM
Compound: FAA (Flavone -8-acetic acid)
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In vitro cytotoxicity against the selected tumor cell line LoVoS arising from human colon adenocarcinoma was determined
In vitro cytotoxicity against the selected tumor cell line LoVoS arising from human colon adenocarcinoma was determined
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[PMID: 12904070] |
| MAC15A | IC50 |
150 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit MAC 15 A cells
In vitro concentration required to inhibit MAC 15 A cells
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10.1016/0960-894X(94)85031-3 |
| MAC16 | IC50 |
180 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit MAC 16 cells
In vitro concentration required to inhibit MAC 16 cells
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10.1016/0960-894X(94)85031-3 |
| MAC26 | IC50 |
208 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
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In vitro concentration required to inhibit MAC 26 cells
In vitro concentration required to inhibit MAC 26 cells
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10.1016/0960-894X(94)85031-3 |
Chemical Information
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CAS No. 87626-55-9
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Appearance Solid
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Molecular Weight 280.27
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Formula C17H12O4
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Color White to off-white
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SMILES
O=C1C2=C(C(CC(O)=O)=CC=C2)OC(C3=CC=CC=C3)=C1
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Synonyms
Flavoneacetic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 70 mg/mL (249.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5680 mL | 17.8399 mL | 35.6799 mL | 89.1997 mL |
| 5 mM | 0.7136 mL | 3.5680 mL | 7.1360 mL | 17.8399 mL | |
| 10 mM | 0.3568 mL | 1.7840 mL | 3.5680 mL | 8.9200 mL | |
| 15 mM | 0.2379 mL | 1.1893 mL | 2.3787 mL | 5.9466 mL | |
| 20 mM | 0.1784 mL | 0.8920 mL | 1.7840 mL | 4.4600 mL | |
| 25 mM | 0.1427 mL | 0.7136 mL | 1.4272 mL | 3.5680 mL | |
| 30 mM | 0.1189 mL | 0.5947 mL | 1.1893 mL | 2.9733 mL | |
| 40 mM | 0.0892 mL | 0.4460 mL | 0.8920 mL | 2.2300 mL | |
| 50 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7840 mL | |
| 60 mM | 0.0595 mL | 0.2973 mL | 0.5947 mL | 1.4867 mL | |
| 80 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1150 mL | |
| 100 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8920 mL |
Mitoflaxone Related Classifications
HY-119340 Related Classifications
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