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United States

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Cat. No.: HY-120233

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MK-8876

MK-8876 is an inhibitor of HCV NS5b site D, which can be used in the research of hepatitis C virus .

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1426960-33-9
Formule: C₃₂H₂₄F₂N₄O₅S
Masse moléculaire:614.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

MK-8876 Chemical Structure

CAS No.: 1426960-33-9

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Quantité

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

MK-8876 is an inhibitor of HCV NS5b site D, which can be used in the research of hepatitis C virus ^[1]^[2].

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1426960-33-9
Masse moléculaire 614.62
Formule C₃₂H₂₄F₂N₄O₅S
SMILES

O=C(C1=C(C2=CC=C(F)C=C2)OC3=CC(N(C)S(=O)(C)=O)=C(C4=CC=C5C(C(N6CO5)=CC7=C6C=CC=C7F)=N4)C=C13)NC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. McLaughlin M, Dermenjian R K, Jin Y, et al. Evaluation and control of mutagenic impurities in a development compound: purge factor estimates vs measured amounts[J]. Organic Process Research & Development, 2015, 19(11): 1531-1535.

[2]. Williams M J, et al. Process Development of the HCV NS5B Site D Inhibitor MK-8876[J]. Organic Process Research & Development, 2016, 20(7): 1227-1238.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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