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MPI-0441138

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death.

For research use only. We do not sell to patients.

CAS No.: 827030-33-1
Formula: C₁₆H₁₄ClN₃O
Molecular Weight:299.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MPI-0441138 Chemical Structure

CAS No.: 827030-33-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	1.085 nM Compound: 25g	Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A2780 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
A-431	IC₅₀	1.2 nM Compound: 8	Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
A549	IC₅₀	1.28 nM Compound: 25g	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
HCC827	IC₅₀	1.25 nM Compound: 25g	Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
HCT-116	EC₅₀	0.002 μM Compound: 2b, EPI28265	Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs	[PMID: 18651728]
HCT-116	EC₅₀	0.002 μM Compound: 6b, EP128265, MPI-0441138	Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 19296653]
HCT-116	GI₅₀	0.002 μM Compound: 2b, EPI28265	Growth inhibition of human HCT116 cells after 48 hrs by CellTiter-Glo assay Growth inhibition of human HCT116 cells after 48 hrs by CellTiter-Glo assay	[PMID: 18651728]
HeLa	IC₅₀	0.6 nM Compound: 8	Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
HeLa	IC₅₀	0.6 nM Compound: 8	Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
MDA-MB-435	IC₅₀	0.6 nM Compound: 8	Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
P388	IC₅₀	2.1 nM Compound: 2b, EPI28265	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18651728]
P388	IC₅₀	2.2 nM Compound: 2b, EPI28265	Cytotoxicity against adriamycin-resistant mouse P388 cells expressing p-glycoprotein Cytotoxicity against adriamycin-resistant mouse P388 cells expressing p-glycoprotein	[PMID: 18651728]
SK-OV-3	IC₅₀	0.78 nM Compound: 25g	Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SK-OV-3 cells incubated for 48 hrs by CCK8 assay	[PMID: 38972078]
SK-OV-3	IC₅₀	0.8 nM Compound: 8	Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SK-OV-3	IC₅₀	1.1 nM Compound: 8	Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SNU-398	EC₅₀	0.002 μM Compound: 6b, EP128265, MPI-0441138	Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 19296653]
T47D	EC₅₀	0.002 μM Compound: 2b, EPI28265	Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs	[PMID: 18651728]
T47D	EC₅₀	0.002 μM Compound: 6b, EP128265, MPI-0441138	Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 19296653]
T47D	GI₅₀	0.001 μM Compound: 2b, EPI28265	Growth inhibition of human T47D cells after 48 hrs by CellTiter-Glo assay Growth inhibition of human T47D cells after 48 hrs by CellTiter-Glo assay	[PMID: 18651728]
U-251	IC₅₀	32.5 nM Compound: 8	Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]

In Vitro

MPI-0441138 (5 nM; 72 h) idnuces apoptosis and DNA fragmentation in 22Rv1, MDA-MB-231, Caco-2, and Du145 cells^[1].
MPI-0441138 (5 nM; 1 h) induces AIF and cytochrome c translocation from mitochondria to cytosol and nucleus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

22Rv1, MDA-MB-231, Caco-2, and Du145 cells
Concentration:

5 nM
Incubation Time:

12, 24, 48, or 72 h
Result:

Resulted robust caspase-3 activation and poly(ADP-ribose) polymerase cleavage, induced DNA fragmentation.

Chemical Information

CAS No. 827030-33-1
Molecular Weight 299.75
Formula C₁₆H₁₄ClN₃O
SMILES

CN(C1=CC=C(OC)C=C1)C2=C3C=CC=CC3=NC(Cl)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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