2. Apoptosis
  3. Apoptosis
  4. MPI-0441138

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death.

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MPI-0441138 Chemical Structure

MPI-0441138 Chemical Structure

CAS No. : 827030-33-1

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MPI-0441138 Related Antibodies

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Description

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death[1].

In Vitro

MPI-0441138 (5 nM; 72 h) idnuces apoptosis and DNA fragmentation in 22Rv1, MDA-MB-231, Caco-2, and Du145 cells[1].
MPI-0441138 (5 nM; 1 h) induces AIF and cytochrome c translocation from mitochondria to cytosol and nucleus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPI-0441138 Related Antibodies

Apoptosis Analysis[1]

Cell Line: 22Rv1, MDA-MB-231, Caco-2, and Du145 cells
Concentration: 5 nM
Incubation Time: 12, 24, 48, or 72 h
Result: Resulted robust caspase-3 activation and poly(ADP-ribose) polymerase cleavage, induced DNA fragmentation.
Molecular Weight

299.75

Formula

C16H14ClN3O
CAS No.
SMILES

CN(C1=CC=C(OC)C=C1)C2=C3C=CC=CC3=NC(Cl)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MPI-0441138 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPI-0441138827030-33-1MPI0441138MPI 0441138ApoptosisDNA breakagenuclear translocationanti-cancerInhibitorinhibitorinhibit

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