2. GPCR/G Protein
  3. Adenosine Receptor
  4. MRS1334

MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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MRS1334

MRS1334 화학구조

CAS No. : 192053-05-7

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MRS1334 Related Antibodies

Top Publications Citing Use of Products

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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  • 순도&문서

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제품 설명

MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment[1][2]. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

hA3

2.69 nM (Ki)

rA1

>100 nM (Ki)

rA2A

>100 nM (Ki)

분자량

522.55

화학식

C31H26N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)NC(C2=CC=CC=C2)=C(C(OCC3=CC=C([N+]([O-])=O)C=C3)=O)C1C#CC4=CC=CC=C4)OCC
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 52 mg/mL (99.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9137 mL 9.5685 mL 19.1369 mL
5 mM 0.3827 mL 1.9137 mL 3.8274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9137 mL 9.5685 mL 19.1369 mL 47.8423 mL
5 mM 0.3827 mL 1.9137 mL 3.8274 mL 9.5685 mL
10 mM 0.1914 mL 0.9568 mL 1.9137 mL 4.7842 mL
15 mM 0.1276 mL 0.6379 mL 1.2758 mL 3.1895 mL
20 mM 0.0957 mL 0.4784 mL 0.9568 mL 2.3921 mL
25 mM 0.0765 mL 0.3827 mL 0.7655 mL 1.9137 mL
30 mM 0.0638 mL 0.3189 mL 0.6379 mL 1.5947 mL
40 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1961 mL
50 mM 0.0383 mL 0.1914 mL 0.3827 mL 0.9568 mL
60 mM 0.0319 mL 0.1595 mL 0.3189 mL 0.7974 mL
80 mM 0.0239 mL 0.1196 mL 0.2392 mL 0.5980 mL
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MRS1334 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS1334192053-05-7MRS 1334MRS-1334Adenosine ReceptorP1 receptoradenosine A3 receptorhA3rA1rA2ACl-IB-MECAbradycardiaST segmentInhibitorinhibitorinhibit

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상품명:
MRS1334
Cat. No.:
HY-103174
수량:
MCE Japan Authorized Agent:

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