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Cat. No.: HY-187107

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Mtb against-2

Mtb against-2 is an (E)-4-oxocrotonic acid derivative that acts as an inhibitor of Mycobacterium tuberculosis protein kinase B (PknB). Mtb against-2 inhibits the growth of Mycobacterium tuberculosis in vitro, with an MIC of 0.82 μg/mL against Mycobacterium tuberculosis H37Rv. Mtb against-2 can be used in tuberculosis-related research.

For research use only. We do not sell to patients.

CAS No.: 89781-43-1
Formula: C₁₄H₁₆O₅
Molecular Weight:264.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mtb against-2 Chemical Structure

CAS No.: 89781-43-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Mtb against-2 (compound 4h) exhibits antibacterial activity against Mycobacterium tuberculosis H37Rv (ATCC27294), with an MIC of 0.82 μg/mL^[1].
Mtb against-2 (compound 9h) (20 mM; 3.5 h) inhibits Mycobacterium tuberculosis protein kinase B (PknB) with an inhibition rate of 68.3% in non-radioactive kinase luminescence assays^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 89781-43-1
Molecular Weight 264.28
Formula C₁₄H₁₆O₅
SMILES

C(/C=C/C(OCC)=O)(=O)C1=CC(OC)=C(OC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ren J, Xu J, Zhang G, Xu C, Zhao L, You X, Wang Y, Lu Y, Yu L, Wang J. Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents. Bioorg Med Chem Lett. 2019 Feb 15;29(4):539-543.

[2]. Xu C, Bai X, Xu J, et al. Substituted 4-oxo-crotonic acid derivatives as a new class of protein kinase B (PknB) inhibitors: synthesis and SAR study[J]. Rsc Advances, 2017, 7(8): 4763-4775.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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