HEPPS
Based on 1 Customer Validation
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 16052-06-5
- Formula: C9H20N2O4S
- Molecular Weight:252.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HEPPS (0-25 μM, 7 days) binds to amyloid-β aggregates and convert them into monomers, thereby reducing the formation of amyloid-β oligomers and plaques. HEPPS rescues cell damage induced by amyloid-β aggregates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-22
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Concentration:25 μM
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Incubation Time:7 days
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Result:Improved the cell viability decreased by amyloid-β oligomers.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:APP/PS1 double transgenic mouse model[1]
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Dosage:30 mg/kg/day
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Administration:po, in drinking water for 3.5 months
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Result:Improved the contextual fear memory deficit, spatial reference memory deficit and spatial working memory deficit of mice.
Reduced Ab oligomer and plaque deposition in the brain of mice.
Reduced glial GABA release in the brain of mice.
Chemical Information
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CAS No. 16052-06-5
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Appearance Solid
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Molecular Weight 252.33
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Formula C9H20N2O4S
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Color White to off-white
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SMILES
O=S(CCCN1CCN(CCO)CC1)(O)=O
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Synonyms
EPPS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 233.33 mg/mL (924.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (396.31 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.9631 mL | 19.8153 mL | 39.6306 mL | 99.0766 mL |
| 5 mM | 0.7926 mL | 3.9631 mL | 7.9261 mL | 19.8153 mL | |
| 10 mM | 0.3963 mL | 1.9815 mL | 3.9631 mL | 9.9077 mL | |
| 15 mM | 0.2642 mL | 1.3210 mL | 2.6420 mL | 6.6051 mL | |
| 20 mM | 0.1982 mL | 0.9908 mL | 1.9815 mL | 4.9538 mL | |
| 25 mM | 0.1585 mL | 0.7926 mL | 1.5852 mL | 3.9631 mL | |
| 30 mM | 0.1321 mL | 0.6605 mL | 1.3210 mL | 3.3026 mL | |
| 40 mM | 0.0991 mL | 0.4954 mL | 0.9908 mL | 2.4769 mL | |
| 50 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9815 mL | |
| 60 mM | 0.0661 mL | 0.3303 mL | 0.6605 mL | 1.6513 mL | |
| 80 mM | 0.0495 mL | 0.2477 mL | 0.4954 mL | 1.2385 mL | |
| 100 mM | 0.0396 mL | 0.1982 mL | 0.3963 mL | 0.9908 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
HEPPS Related Classifications
HY-D0873 Related Classifications
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