N-Isovalerylglycine-d9
Based on 1 Customer Validation
N-Isovalerylglycine-d9 is the deuterium labeled N-Isovaleroylglycine (HY-W015464). N-Isovaleroylglycine is a peptidylglycine α-amidating monooxygenase (PAM) inhibitor with a Ki value of 2.0 mM against human hsPAM. N-Isovaleroylglycine undergoes oxidative cleavage by purified rat PAM to produce fatty acid amide and glyoxylic acid. N-Isovaleroylglycine exerts competitive inhibition by binding to hsPAM, blocking the amidation of dansyl-Tyr-Val-Gly. N-Isovaleroylglycine exhibits lowered urinary abundance in MRSA-infected mice, which qualifies it as a non-invasive biomarker. N-Isovaleroylglycine can be used in studies related to Staphylococcus aureus pneumonia and diabetic foot.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1330037-21-2
- Formula: C7H4D9NO3
- Molecular Weight:168.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1330037-21-2
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Unlabeled Cas 16284-60-9
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Appearance Solid
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Molecular Weight 168.24
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Formula C7H4D9NO3
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Color White to off-white
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SMILES
O=C(O)CNC(C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (594.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Slupsky CM, et al. Streptococcus pneumoniae and Staphylococcus aureus pneumonia induce distinct metabolic responses. Journal of proteome research. 2009 Jun;8(6):3029-36. [Content Brief]
[3]. Lian F, et al. Distinct urine and plasma metabolic signatures in diabetic foot: early diagnostic biomarkers and predictive modeling. BMC endocrine disorders. 2025 Dec 29;25(1):285. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9439 mL | 29.7194 mL | 59.4389 mL | 148.5972 mL |
| 5 mM | 1.1888 mL | 5.9439 mL | 11.8878 mL | 29.7194 mL | |
| 10 mM | 0.5944 mL | 2.9719 mL | 5.9439 mL | 14.8597 mL | |
| 15 mM | 0.3963 mL | 1.9813 mL | 3.9626 mL | 9.9065 mL | |
| 20 mM | 0.2972 mL | 1.4860 mL | 2.9719 mL | 7.4299 mL | |
| 25 mM | 0.2378 mL | 1.1888 mL | 2.3776 mL | 5.9439 mL | |
| 30 mM | 0.1981 mL | 0.9906 mL | 1.9813 mL | 4.9532 mL | |
| 40 mM | 0.1486 mL | 0.7430 mL | 1.4860 mL | 3.7149 mL | |
| 50 mM | 0.1189 mL | 0.5944 mL | 1.1888 mL | 2.9719 mL | |
| 60 mM | 0.0991 mL | 0.4953 mL | 0.9906 mL | 2.4766 mL | |
| 80 mM | 0.0743 mL | 0.3715 mL | 0.7430 mL | 1.8575 mL | |
| 100 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4860 mL |
N-Isovalerylglycine-d9 Related Classifications
HY-W015464S Related Classifications
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